Arotinolol

Arotinolol
(IUPAC) ime
	(RS)-5-(2[3-(tert-butilamino)-2-hidroksipropil]sulfanil 1,3-tiazol-4-il)tiofen-2-karboksamid
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	41287-43-8
ATC kod	nije dodeljen
PubChem	2239
ChemSpider	2152
UNII	394E3P3B99
KEGG	D07465
ChEMBL	CHEMBL93298
Hemijski podaci
Formula	C15H21N3O2S3
Mol. masa	371,54 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20) ; Key: BHIAIPWSVYSKJS-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	2 h
Poluvreme eliminacije	10 h
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Arotinolol (Almarl) je lek u klasi mešovitih alfa/beta blokatora.^[6]

Upotreba uredi

On se koristi za tretman visokog krvnog pritiska.^[7] Predloženo je da se on može koristiti za treatman esencijalnog tremora.^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001). „Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes”. Can. J. Physiol. Pharmacol. 79 (7): 585–93. DOI:10.1139/cjpp-79-7-585. PMID 11478592.
↑ Wu H, Zhang Y, Huang J, et al. (September 2001). „Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers”. Hypertens. Res. 24 (5): 605–10. DOI:10.1291/hypres.24.605. PMID 11675958. - ^{Scholar search}}}
↑ Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). „A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor”. Parkinsonism Relat. Disord. 9 (6): 341–7. DOI:10.1016/S1353-8020(03)00029-4. PMID 12853233.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

Almarl アルマール Arhivirano 2012-02-16 na Wayback Machine-u (PDF)
Official Dainippon Sumitomo Pharma Website Arhivirano 2020-07-01 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid11478592-6] Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001). „Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes”. Can. J. Physiol. Pharmacol. 79 (7): 585–93. DOI:10.1139/cjpp-79-7-585. PMID 11478592.

[pmid11675958-7] Wu H, Zhang Y, Huang J, et al. (September 2001). „Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers”. Hypertens. Res. 24 (5): 605–10. DOI:10.1291/hypres.24.605. PMID 11675958. - ^{Scholar search}}}

[pmid12853233-8] Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). „A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor”. Parkinsonism Relat. Disord. 9 (6): 341–7. DOI:10.1016/S1353-8020(03)00029-4. PMID 12853233.

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