Nespecifična peroksigenaza
(Preusmjereno sa stranice Aromatična peroksigenaza)
Nespecifična peroksigenaza (EC 1.11.2.1, aromatična peroksigenaza, peroksigenaza pečurki, haloperoksidaza-peroksigenaza, Agrocybe aegerita peroksidaza) je enzim sa sistematskim imenom supstrat:vodonik peroksid oksidoreduktaza (RH-hidroksilacija ili epoksidacija).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Nespecifična peroksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.2.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- RH + H2O2 ROH + H2O
Ovaj enzim je hem-tiolatni protein (P450). Enzimi ovog tipa obuhvataju glikoproteine koje luči agarski Basidiomycetes. Oni katalizuju umetanja atoma kiseonika iz H2O2 u mnoštvo različitih supstrata, uključujući aromatične prstene kao što su naftalen, toluen, fenantren, piren i p-nitrofenol,.
Reference uredi
- ↑ Ullrich, R., Nuske, J., Scheibner, K., Spantzel, J. and Hofrichter, M. (2004). „Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes”. Appl. Environ. Microbiol. 70: 4575-4581. PMID 15294788.
- ↑ Ullrich, R. and Hofrichter, M. (2005). „The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene”. FEBS Lett. 579: 6247-6250. PMID 16253244.
- ↑ Anh, D.H., Ullrich, R., Benndorf, D., Svatos, A., Muck, A. and Hofrichter, M. (2007). „The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation”. Appl. Environ. Microbiol. 73: 5477-5485. PMID 17601809.
- ↑ Ullrich, R., Dolge, C., Kluge, M. and Hofrichter, M. (2008). „Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita”. FEBS Lett. 582: 4100-4106. PMID 19022254.
- ↑ Aranda, E., Kinne, M., Kluge, M., Ullrich, R. and Hofrichter, M. (2009). „Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases”. Appl. Microbiol. Biotechnol. 82: 1057-1066. PMID 19039585.
- ↑ Kinne, M., Poraj-Kobielska, M., Aranda, E., Ullrich, R., Hammel, K.E., Scheibner, K. and Hofrichter, M. (2009). „Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase”. Bioorg. Med. Chem. Lett. 19: 3085-3087. PMID 19394224.
- ↑ Kluge, M., Ullrich, R., Dolge, C., Scheibner, K. and Hofrichter, M. (2009). „Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation”. Appl. Microbiol. Biotechnol. 81: 1071-1076. PMID 18815784.
- ↑ Kinne, M., Poraj-Kobielska, M., Ralph, S.A., Ullrich, R., Hofrichter, M. and Hammel, K.E. (2009). „Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase”. J. Biol. Chem. 284: 29343-29349. PMID 19713216.
- ↑ Pecyna, M.J., Ullrich, R., Bittner, B., Clemens, A., Scheibner, K., Schubert, R. and Hofrichter, M. (2009). „Molecular characterization of aromatic peroxygenase from Agrocybe aegerita”. Appl. Microbiol. Biotechnol. 84: 885-897. PMID 19434406.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.