Aralkilamin dehidrogenaza (azurin)
Aralkilamin dehidrogenaza (azurin) (EC 1.4.9.2, aromatična aminska dehidrogenaza, arilaminska dehidrogenaza, tiraminska dehidrogenaza, aralkilamin:(akceptor) oksidoreduktaza (deaminacija)) je enzim sa sistematskim imenom aralkilamin:azurin oksidoreduktaza (deaminacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aralkilamin dehidrogenaza (azurin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.9.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ArCH2NH2 + H2O + 2 azurin ArCHO + NH3 + 2 redukovani azurin
Fenazinski metosulfat može da deluje kao akceptor. Ovaj enzim deluje na aromatične amine i u manjoj meri na pojedine dugolančane alifatične amine.
Reference
uredi- ↑ Iwaki, M., Yagi, T., Horiike, K., Saeki, Y., Ushijima, T. and Nozaki, M. (1983). „Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp”. Arch. Biochem. Biophys. 220: 253-262. PMID 6830237.
- ↑ Hyun, Y.L. and Davidson, V.L. (1995). „Electron transfer reactions between aromatic amine dehydrogenase and azurin”. Biochemistry 34: 12249-12254. PMID 7547967.
- ↑ Hyun, Y.L., Zhu, Z. and Davidson, V.L. (1999). „Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin”. J. Biol. Chem. 274: 29081-29086. PMID 10506161.
- ↑ Davidson, V.L. (2004). „Electron transfer in quinoproteins”. Arch. Biochem. Biophys. 428: 32-40. PMID 15234267.
- ↑ Sukumar, N., Chen, Z.W., Ferrari, D., Merli, A., Rossi, G.L., Bellamy, H.D., Chistoserdov, A., Davidson, V.L. and Mathews, F.S. (2006). „Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis”. Biochemistry 45: 13500-13510. PMID 17087503.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.