Aminofilin

Aminofilin
(IUPAC) ime
	1,3-dimetil-7H-purin-2,6-dion; ethan-1,2-diamin
Klinički podaci
AHFS/Drugs.com	Potrošačka informacije o leku
MedlinePlus	a601015
Identifikatori
CAS broj	317-34-0
ATC kod	R03DA05
PubChem	9433
DrugBank	DB01223
ChemSpider	9062
UNII	27Y3KJK423
KEGG	D00227
ChEMBL	CHEMBL1210
Hemijski podaci
Formula	C16H24N10O4
Mol. masa	420,427 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/2C7H8N4O2.C2H8N2/c21-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h23H,1-2H3,(H,8,9);1-4H2 ; Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	60%
Poluvreme eliminacije	7-9 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	P (UK)
Način primene	oralno, i.v.

Aminofilin je bronhodilatator. On se sastoji od teofilina sa etilendiaminom u odnosu 2:1. Etilendiamin poboljšava rastvorljivost. Aminofilin se obično nalazi kao dihidrat^[6] Aminofilin je neselektivan antagonist adenozinskog receptora i inhibitor fosfodiesteraze.^[7]^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Aminophylline Professional Monograph”.
↑ ^7,0 ^7,1 Mader, TJ; Smithline HA, Durkin L, Scriver G (March 2003). „A randomized control trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest”. Academic Emergency Medical Journal 10 (3): 192–197. Arhivirano iz originala na datum 2017-06-10. Pristupljeno 2012-02-10.
↑ Mader, TJ; Gibson, P (January 1997). cws_home/505959/description#description „Adenosine receptor antagonism in refractory asystolic cardiac arrest: results of a human pilot study”. Elsevier Resuscitation 35: 3–7. Pristupljeno 2012-02-10.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] „Aminophylline Professional Monograph”.

[Mader_2003_192–197-7] 7,0 ^7,1 Mader, TJ; Smithline HA, Durkin L, Scriver G (March 2003). „A randomized control trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest”. Academic Emergency Medical Journal 10 (3): 192–197. Arhivirano iz originala na datum 2017-06-10. Pristupljeno 2012-02-10.

[Mader_1997_3–7-8] Mader, TJ; Gibson, P (January 1997). cws_home/505959/description#description „Adenosine receptor antagonism in refractory asystolic cardiac arrest: results of a human pilot study”. Elsevier Resuscitation 35: 3–7. Pristupljeno 2012-02-10.

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