Alglukozidaza alfa
Alglukozidaza alfa (Lumizyme, Myozyme) orfanski lek je za terapiju enzimske zamene kojom se tretira Pompeova bolest (glikogenoza tipa II), retko nasledno metaboličko oboljenje.[1] Alglukozidaza alfa se sastoji od ljudskog enzima, kisele a-glukozidaze (GAA). Ona se proizvodi primenom rekombinantne DNK tehnologije na CHO ćelija.[2][3][4]
| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | alfa.html Monografija |
| Identifikatori | |
| CAS broj | 420784-05-0 |
| ATC kod | A16AB07 |
| DrugBank | DB01272 |
| Hemijski podaci | |
| Formula | C4758H7262N1274O1369S35 |
| Mol. masa | 105338 |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 2,3-0,4 h |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Intravenozno |
Reference uredi
- ↑ Kishnani PS, D, Corzo, M, Nicolino i dr.. (2007). „Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease”. Neurology 68 (2): 99–109. DOI:10.1212/01.wnl.0000251268.41188.04. PMID 17151339.
- ↑ Kishnani PS, Corzo D, Nicolino M, Byrne B, Mandel H, Hwu WL, Leslie N, Levine J, Spencer C, McDonald M, Li J, Dumontier J, Halberthal M, Chien YH, Hopkin R, Vijayaraghavan S, Gruskin D, Bartholomew D, van der Ploeg A, Clancy JP, Parini R, Morin G, Beck M, De la Gastine GS, Jokic M, Thurberg B, Richards S, Bali D, Davison M, Worden MA, Chen YT, Wraith JE: Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology. 2007 Jan 9;68(2):99-109. Epub 2006 Dec 6. PMID 17151339
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura uredi
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
