Adrenorfin (metorfam​id) je endogeni, C-terminalno amidisani, opioidni oktapeptid (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2). On nastaje proteolitičim presecanjem proenkefalina A. Adrenorfin je široko rasprostranjen u mozgu sisara.[4][5][6][7][8]

Adrenorfin
Adrenorphin slim.svg
IUPAC ime
Identifikacija
CAS registarski broj 88377-68-8
PubChem[1][2] 122176
ChemSpider[3] 108968 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C44H69N15O9S
Molarna masa 984,18 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Dobio je ime po činjenici da je originalno nađen u humanom feohromocitomnom tumoru izvedenom iz srži nadbubrežne žlezde. Naknadno je utvrđeno da je isto tako prisutan u normalnoj humanoj i goveđoj adrenalnoj meduli.[4] Adrenorfin ima potentno opioidno dejstvo. On deluje kao balansirani agonist μ- i κ-opioidnog receptora, a nema efekta na δ-opioidne receptore.[5] On ispoljava analgetičke i respiratorno depresantske efekte.[9]

Vidi jošUredi

LiteraturaUredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. 4,0 4,1 Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3. PMID 6633641. 
  5. 5,0 5,1 Weber E, Esch FS, Böhlen P, et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6. PMC 390055. PMID 6316361. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=6316361. 
  6. Sonders M, Barchas JD, Weber E (August 1984). "Regional distribution of metorphamide in rat and guinea pig brain". Biochemical and Biophysical Research Communications 122 (3): 892–8. DOI:10.1016/0006-291X(84)91174-4. PMID 6477570. http://linkinghub.elsevier.com/retrieve/pii/0006-291X(84)91174-4. 
  7. Miyata A, Mizuno K, Minamino N, Matsuo H (May 1984). "Regional distribution of adrenorphin in rat brain: comparative study with PH-8P". Biochemical and Biophysical Research Communications 120 (3): 1030–6. DOI:10.1016/S0006-291X(84)80210-7. PMID 6732783. http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(84)80210-7. 
  8. Miyata A, Mizuno K, Honzawa M, Tohyama M, Matsuo H (February 1985). "Adrenorphin immunoreactivity in rat brain". Neuropeptides 5 (4-6): 517–20. PMID 2860609. http://linkinghub.elsevier.com/retrieve/pii/0143-4179(85)90068-X. 
  9. Xu SF, Lu WX, Zhou KR, et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31. PMID 4000426.