Acil-KoA dehidrogenaza srednje dugog lanca
Acil-KoA dehidrogenaza srednje dugog lanca (EC 1.3.8.7, masna acil koenzim A dehidrogenaza (nespecifična), acil koenzim A dehidrogenaza (nespecifična), acil dehidrogenaza (nespecifična), masna-acil-KoA dehidrogenaza (nespecifična), acil KoA dehidrogenaza (nespecifična), general acil KoA dehidrogenaza (nespecifična), acil-koenzim A dehidrogenaza srednje dugog lanca, acil-KoA:(akceptor) 2,3-oksidoreduktaza (nespecifična), ACADM (gen).) je enzim sa sistematskim imenom acil-KoA srednje dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acil-KoA dehidrogenaza srednje dugog lanca | |||||||||
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| Tetramer acil-KoA dehidrogenaze srednje dugog lanca (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- acil-KoA srednje dugog lanca + elektron-transfer flavoprotein trans-2,3-dehidroacil-KoA srednje dugog lanca + redukovani elektron-transfer flavoprotein
Ovaj enzim sadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi korak u beta oksidaciji masnih kiselina. Enzim iz jetre svinja može da deluje na supstrat sa acil lancom dožine 4 do 16 ugljenika, ali je najaktivniji na jedinjenjima sa C8 do C12 dugim lancom.
Reference uredi
- ↑ Crane, F.L., Hauge, J.G. and Beinert, H. (1955). „Flavoproteins involved in the first oxidative step of the fatty acid cycle”. Biochim. Biophys. Acta 17: 292-294. PMID 13239683.
- ↑ Crane, F.L., Mii, S., Hauge, J.G., Green, D.E. and Beinert, H. (1956). „On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase”. J. Biol. Chem. 218: 701-716. PMID 13295224.
- ↑ Beinert, H. (1963). „Acyl coenzyme A dehydrogenase”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 7 (2nd izd.). New York: Academic Press. str. 447-466.
- ↑ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). „Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme”. J. Biol. Chem. 260: 1311-1325. PMID 3968063.
- ↑ Thorpe, C. and Kim, J.J. (1995). „Structure and mechanism of action of the acyl-CoA dehydrogenases”. FASEB J. 9: 718-725. PMID 7601336.
- ↑ Kim, J.J., Wang, M. and Paschke, R. (1993). „Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate”. Proc. Natl. Acad. Sci. USA 90: 7523-7527. PMID 8356049.
- ↑ Peterson, K.L., Sergienko, E.E., Wu, Y., Kumar, N.R., Strauss, A.W., Oleson, A.E., Muhonen, W.W., Shabb, J.B. and Srivastava, D.K. (1995). „Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules”. Biochemistry 34: 14942-14953. PMID 7578106.
- ↑ Toogood, H.S., van Thiel, A., Basran, J., Sutcliffe, M.J., Scrutton, N.S. and Leys, D. (2004). „Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex”. J. Biol. Chem. 279: 32904-32912. PMID 15159392.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.