Acetilserotonin O-metiltransferaza
Acetilserotonin O-metiltransferaza (EC 2.1.1.4, hidroksiindolna metiltransferaza, hidroksiindolna O-metiltransferaza, N-acetilserotoninska O-metiltransferaza, acetilserotoninska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:N-acetilserotonin O-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acetilserotonin O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.4 | ||||||||
| CAS broj | 9029-77-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + N-acetilserotonin S-adenozil-L-homocistein + melatonin
Neki drugi hidroksiindoli takođe deluju kao akceptor, mada sporije.
Reference uredi
- ↑ Axelrod, J. and Weissbach, H. (1961). „Purification and properties of hydroxyindole-O-methyl transferase”. J. Biol. Chem. 236: 211-213. PMID 13685335.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.