AM-855 je analgetik koji je kanabinoidni agonist. On je derivat Δ8Tetrahidrokanabinola sa konformaciono ograničenim bočnim lancom. AM-855 je agonist CB1 i CB2 sa umerenom selektivnošću za CB1, Ki od 22,3 nM na CB1 i 58,6 nM na CB2.[5]
AM-855
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(IUPAC) ime
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(4aR,12bR)-8-heksil-2,5,5-trimetil-1,4,4a,8,9,10,11,12b-oktahidronafto[3,2-c]izohromen-12-ol
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Klinički podaci
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Identifikatori
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ATC kod
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?
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PubChem[1][2] |
10091328
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ChemSpider[3] |
8266865
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ChEMBL[4] |
CHEMBL303479 Y |
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Hemijski podaci
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Formula
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C26H38O2 |
Mol. masa
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382,577 g/mol-
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SMILES
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eMolekuli & PubHem
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InChI |
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InChI=1S/C26H38O2/c1-5-6-7-8-10-18-11-9-12-19-20(18)16-23-24(25(19)27)21-15-17(2)13-14-22(21)26(3,4)28-23/h13,16,18,21-22,27H,5-12,14-15H2,1-4H3/t18?,21-,22-/m1/s1 Y Key: GAAJNVWIOIOMPO-IPKCRJEZSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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References
uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Khanolkara, Atmaram D.; Dai Lua, Pusheng Fana, Xiaoyu Tiana and Alexandros Makriyannis (August 1999). „Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol”. Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. DOI:10.1016/S0960-894X(99)00355-8. PMID 10465529.