6-Metilsalicilna kiselina sintaza
(Preusmjereno sa stranice 6-metilsalicilna kiselina sintaza)
6-Metilsalicilna kiselina sintaza (EC 2.3.1.165, MSAS, 6-metilsalicilno kiselinska sintaza) je enzim sa sistematskim imenom acil-KoA:malonil-KoA C-aciltransferaza (dekarboksilacija, oksoacilna redukcija, tioestarska hidroliza i ciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6-Metilsalicilna kiselina sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.165 | ||||||||
| CAS broj | 9045-37-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + 3 malonil-KoA + NADPH + H+ 6-metilsalicilat + 4 KoA + 3 CO2 + NADP+ +H2O
Ovaj multienzimski kompleks sadrži 4'-fosfopanteteinsku prostetičku grupu.
Reference uredi
- ↑ Spencer, J.B. and Jordan, P.M. (1992). „Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum”. Biochem. J. 288: 839-846. PMID 1471999.
- ↑ Child, C.J., Spencer, J.B., Bhogal, P. and Shoolingin-Jordan, P.M. (1996). „Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies”. Biochemistry 35: 12267-12274. PMID 8823160.
- ↑ Richardson, M.T., Pohl, N.L., Kealey, J.T. and Khosla, C. (1999). „Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase”. Metab. Eng. 1: 180-187. PMID 10935930.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.