3F8
3F8 je glodarsko IgG3[1] monoklonalno antitelo koje se vezuje za GD2.[2]
| Monoklonalna antitela | |
|---|---|
| Izvor | miš |
| Odredište | GD2 |
| Klinički podaci | |
| Identifikatori | |
| ATC kod | nije dodeljen |
| Hemijski podaci | |
| Formula | ? |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | intravenozno |
3F8 antitelo je korišteno za detekciju i tretman neuroblastoma. Kad se koristi za snimanje neuroblastoma, ono je obeleženo sa jednim od radioizotopa jod-124 ili jod-131.[3][4]
Reference uredi
- ↑ Kushner BH, Cheung NK (1989). „GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma”. Blood 73 (7): 1936–41. PMID 2653466.
- ↑ „Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A”. Pristupljeno 19. 2. 2008.
- ↑ Yeh SD, Larson SM, Burch L i dr.. (1991). „Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities”. J. Nucl. Med. 32 (5): 769–76. PMID 1902508.
- ↑ Dauer LT, St Germain J, Williamson MJ i dr.. (2007). „Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma”. Health Phys 92 (1): 33–9. DOI:10.1097/01.HP.0000231583.32904.6c. PMID 17164597.