3'-demetilstaurosporin O-metiltransferaza
3'-demetilstaurosporin O-metiltransferaza (EC 2.1.1.139, 3'-demetoksi-3'-hidroksistaurosporinska O-metiltransferaza, staurosporinska sintaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3'-demetilstaurosporin O-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3'-demetilstaurosporin O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.139 | ||||||||
| CAS broj | 212906-74-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 3'-demetilstaurosporin S-adenozil-L-homocistein + staurosporin
Ovaj enzim katalizuje finalni korak biosinteze staurosporina.
Reference uredi
- ↑ Weidner, S., Kittelmann, M., Goeke, K., Ghisalba, O. and Zahner, H. (1998). „3′-Demethoxy-3′-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine”. J. Antibiot. (Tokyo) 51: 679-682. PMID 9727395.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.