23S rRNK (guanozin2251-2'-O)-metiltransferaza
23S rRNK (guanozin2251-2'-O)-metiltransferaza (EC 2.1.1.185, rlmB (gen), yifH (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanozin2251-2'-O-)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 23S rRNK (guanozin2251-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.185 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + guanozin2251 u 23S rRNK S-adenozil-L-homocistein + 2'-O-metilguanozin2251 u 23S rRNK
Enzim katalizuje metilaciju guanozina2251. Ta modifikacija je konzervirana u peptidiltransferaznom domenu 23S rRNK.
Reference uredi
- ↑ Lovgren, J.M. and Wikstrom, P.M. (2001). „The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli”. J. Bacteriol. 183: 6957-6960. PMID 11698387.
- ↑ Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. (2002). „The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot”. Structure 10: 1303-1315. PMID 12377117.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.