23S rRNK (guanin745-N1)-metiltransferaza
23S rRNK (guanin745-N1)-metiltransferaza (EC 2.1.1.187, Rlma(I), Rlma1, 23S rRNK m1G745 metiltransferaza, YebH, RlmAI metiltransferaza, ribozomalna RNK(m1G)-metilaza (nespecifična), rRNK(m1G)metilaza (nespecifična), RrmA (nespecifična), 23S rRNK:m1G745 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin745-N1)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 23S rRNK (guanin745-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.187 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + guanin745 u 23S rRNK S-adenozil-L-homocistein + N1-metilguanin745 u 23S rRNK
Ovaj enzim specifično metiliše guanin745 u N1 poziciji 23S rRNK.
Reference uredi
- ↑ Liu, M., Novotny, G.W. and Douthwaite, S. (2004). „Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase”. RNA 10: 1713-1720. PMID 15388872.
- ↑ Gustafsson, C. and Persson, B.C. (1998). „Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant”. J. Bacteriol. 180: 359-365. PMID 9440525.
- ↑ Das, K., Acton, T., Chiang, Y., Shih, L., Arnold, E. and Montelione, G.T. (2004). „Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site”. Proc. Natl. Acad. Sci. USA 101: 4041-4046. PMID 14999102.
- ↑ Hansen, L.H., Kirpekar, F. and Douthwaite, S. (2001). „Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase”. J. Mol. Biol. 310: 1001-1010. PMID 11501991.
- ↑ Liu, M. and Douthwaite, S. (2002). „Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria”. Mol. Microbiol. 44: 195-204. PMID 11967079.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.