23S rRNK (adenin2085-N6)-dimetiltransferaza

23S rRNK (adenin2085-N6)-dimetiltransferaza (EC 2.1.1.184, ErmC' metiltransferaza, ermC metilaza, ermC 23S rRNK metiltransferaza, rRNK:m6A metiltransferaza ErmC' , ErmC' , rRNK metiltransferaza ErmC' ) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenin2085-N6)-dimetiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

23S rRNK (adenin2085-N6)-dimetiltransferaza
Identifikatori
EC broj 2.1.1.184
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
2 S-adenozil-L-metionin + adenin2085 u 23S rRNK 2 S-adenozil-L-homocistein + N6-dimetiladenin2085 u 23S rRNK

ErmC je metiltransferaza koja pruža otpornost na makrolid-linkozamid-streptograminsku B grupu antibiotika tako što katalizuje metilaciju 23S rRNK na adeninu2085.

Reference uredi

  1. Zhong, P., Pratt, S.D., Edalji, R.P., Walter, K.A., Holzman, T.F., Shivakumar, A.G. and Katz, L. (1995). „Substrate requirements for ErmC′ methyltransferase activity”. J. Bacteriol. 177: 4327-4332. PMID 7543473. 
  2. Denoya, C. and Dubnau, D. (1989). „Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase”. J. Biol. Chem. 264: 2615-2624. PMID 2492520. 
  3. Denoya, C.D. and Dubnau, D. (1987). „Site and substrate specificity of the ermC 23S rRNA methyltransferase”. J. Bacteriol. 169: 3857-3860. PMID 2440853. 
  4. Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Nienaber, V.L., Edalji, R.P., Walter, K.A., Ladror, U.S., Holzman, T.F. and Abad-Zapatero, C. (1998). „Crystal structure of ErmC′, an rRNA methyltransferase which mediates antibiotic resistance in bacteria”. Biochemistry 37: 7103-7112. PMID 9585521. 
  5. Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J. and Abad-Zapatero, C. (1999). „The 2.2 Å structure of the rRNA methyltransferase ErmC′ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism”. J. Mol. Biol. 289: 277-291. PMID 10366505. 
  6. Maravic, G., Bujnicki, J.M., Feder, M., Pongor, S. and Flogel, M. (2003). „Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC′ redefines the substrate-binding site and suggests a model for protein-RNA interactions”. Nucleic Acids Res. 31: 4941-4949. PMID 12907737. 

Literatura uredi

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