2-Sukcinil-5-enolpiruvil-6-hidroksi-3-cikloheksen-1-karboksilna-kiselina sintaza
2-Sukcinil-5-enolpiruvil-6-hidroksi-3-cikloheksen-1-karboksilna-kiselina sintaza (EC 2.2.1.9, SEPHCHC sintaza, MenD) je enzim sa sistematskim imenom isochorismate:2-oksoglutarat 4-oksopentanoattransferaza (dekarboksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Sukcinil-5-enolpiruvil-6-hidroksi-3-cikloheksen-1-karboksilna-kiselina sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.9 | ||||||||
| CAS broj | 1112282-73-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- izohorizmat + 2-oksoglutarat 5-enolpiruvoil-6-hidroksi-2-sukcinil-cikloheks-3-en-1-karboksilat + CO2
Za rad ovog enzima je neophodan Mg2+. Enzim učestvuje u biosintezi vitamina K2 (menahinona).
Reference uredi
- ↑ Jiang, M., Cao, Y., Guo, Z.F., Chen, M., Chen, X. and Guo, Z. (2007). „Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity”. Biochemistry 46: 10979-10989. PMID 17760421.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.