2-Ketoarginin metiltransferaza
2-Ketoarginin metiltransferaza (EC 2.1.1.243, mrsA (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:5-karbamimidamido-2-oksopentanoat S-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Ketoarginin metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.243 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 5-guanidino-2-oksopentanoat S-adenozil-L-homocistein + 5-guanidino-3-metil-2-oksopentanoat
Ovaj enzim učestvuje u produkciji retke aminokiseline 3-metilarginina, koju koristi epifitna bakterija Pseudomonas syringae pv. Syringae kao antibiotik protiv srodnih patogenih vrsta Pseudomonas syringae pv. Glicina.
Reference uredi
- ↑ Braun, S.D., Hofmann, J., Wensing, A., Ullrich, M.S., Weingart, H., Völksch, B. and Spiteller, D. (2010). „Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae' pv. syringae 22d/93”. Appl. Environ. Microbiol. 76: 2500-2508. PMID 20190091.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.