18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza

18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza (EC 2.1.1.183, 18S rRNK dimetilaza Dim1p, Dim1p, ScDim1, m2(6)A dimetilaza, KIDIM1) je enzim sa sistematskim imenom S-adenozil-L-metionin:18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza
Identifikatori
EC broj 2.1.1.183
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
4 S-adenozil-L-metionin + adenin1779/adenin1780 u 18S rRNK 4 S-adenozil-L-homocistein + N6-dimetiladenin1779/N6-dimetiladenin1780 u 18S rRNK

DIM1 učestvuje u pre-rRNK transformacijama.

Reference uredi

  1. Lafontaine, D., Vandenhaute, J. and Tollervey, D. (1995). „The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast”. Genes Dev. 9: 2470-2481. PMID 7590228. 
  2. Lafontaine, D.L., Preiss, T. and Tollervey, D. (1998). „Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis”. Mol. Cell Biol. 18: 2360-2370. PMID 9528805. 
  3. Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. (2009). „Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases”. J. Mol. Biol. 391: 884-893. PMID 19520088. 
  4. Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. (1994). „The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast”. J. Mol. Biol. 241: 492-497. PMID 8064863. 
  5. O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. (2006). „Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution”. RNA 12: 725-733. PMID 16540698. 

Literatura uredi

Spoljašnje veze uredi