3(ili 17)b-hidroksisteroid dehidrogenaza
(Preusmjereno sa stranice 17β-hidroksisteroid dehidrogenaza)
3(ili 17)b-hidroksisteroid dehidrogenaza (EC 1.1.1.51, beta-hidroksi steroidna dehidrogenaza, 17-ketoreduktaza, 17beta-hidroksi steroidna dehidrogenaza, 3beta-hidroksisteroidna dehidrogenaza, 3beta-hidroksi steroidna dehidrogenaza) je enzim sa sistematskim imenom 3(or 17)beta-hidroksisteroid:NAD(P)+ oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3(ili 17)b-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.51 | ||||||||
| CAS broj | 9015-81-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- testosteron + NAD(P)+ androstendion + NAD(P)H + H+
Takođe deluje na druge 3beta- ili 17beta-hidroksisteroide, cf. EC 1.1.1.209 3(ili 17)alfa-hidroksisteroidna dehidrogenaza.
Reference uredi
- ↑ Dahm, K. and Breuer, H. (1964). „Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte”. Hoppe-Seyler's Z. Physiol. Chem. 336: 63-68. PMID 14214322.
- ↑ Lynn, W.S. and Brown, R.H. (1958). „The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015-1030. PMID 13549484.
- ↑ Marcus, P.I. and Talalay, P. (1956). „Induction and purification of α- and β-hydroxysteroid dehydrogenases”. J. Biol. Chem. 218: 661-674. PMID 13295221.
- ↑ Schultz, R.M., Groman, F.V. and Engel, L.L. (1977). „3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms”. J. Biol. Chem. 252: 3775-3783. PMID 193845.
- ↑ Talalay, P. and Dobson, M.M. (1953). „Purification and properties of a α-hydroxysteroid dehydrogenase”. J. Biol. Chem. 205: 823-837. PMID 13129261.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.