16S rRNK (guanin527-N7)-metiltransferaza
16S rRNK (guanin527-N7)-metiltransferaza (EC 2.1.1.170, metiltransferaza G ribozomalne RNK male podjedinice, 16S rRNK metiltransferaza RsmG, GidB, rsmG (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:16S rRNK (guanin527-N7)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 16S rRNK (guanin527-N7)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.170 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + guanin527 u 16S rRNK S-adenozil-L-homocistein + N7-metilguanin527 u 16S rRNK
Ovaj enzim specifično metiliše guanin527 u N7 poziciju u 16S rRNK.
Reference uredi
- ↑ Okamoto, S., Tamaru, A., Nakajima, C., Nishimura, K., Tanaka, Y., Tokuyama, S., Suzuki, Y. and Ochi, K. (2007). „Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria”. Mol. Microbiol. 63: 1096-1106. PMID 17238915.
- ↑ Romanowski, M.J., Bonanno, J.B. and Burley, S.K. (2002). „Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold”. Proteins 47: 563-567. PMID 12001236.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.