11-Dehidrotromboksan B2

11-Dehidrotromboksan B2
	(Z)-7-[(2R,3S,4S)-4-hidroksi-2-[(E,3S)-3-hidroksiokt-1-enil]-6-okso-tetrahidropiran-3-il]hept-5-enoinska kiselina
Drugi nazivi	11-Dehidro-tromboksan B2
Identifikacija
CAS registarski broj	67910-12-7
PubChem	5280891
ChemSpider	4444414
KEGG	C05964
ChEBI	28667
Jmol-3D slike	Slika 1
SMILES
	O=C1O[C@H](/C=C/[C@@H](O)CCCCC)[C@H]([C@@H](O)C1)C\C=C/CCCC(=O)O
InChI
	InChI=1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1 ; Kod: KJYIVXDPWBUJBQ-UHHGALCXSA-N InChI=1/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1; Kod: KJYIVXDPWBUJBQ-UHHGALCXBE
Svojstva
Molekulska formula	C20H32O6
Molarna masa	368.46 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

11-dehidrotromboksan B2 (11-dehidro-TXB2) se formira razlaganjem tromboksana A2. Njega otpušataju aktivirani trombociti. Urinski nivoi 11-dehidro-TXB2 se mogu koristiti za praćenje responsa na terapiju aspirinom, kad se koristi za sprečavanje srčane bolesti,^[5] kao i bolesti kod kojih je prominentna aktivacija trombocita.^[6]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). „A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease”. Eur Heart J 28 (14): 1702–1708. DOI:10.1093/eurheartj/ehm226. PMID 17569678.
↑ Catella F, Healy D, Lawson JA, FitzGerald GA (1986). „11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation”. PNAS 83 (16): 5861–5865. DOI:10.1073/pnas.83.16.5861. PMC 386396. PMID 3461463.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). „A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease”. Eur Heart J 28 (14): 1702–1708. DOI:10.1093/eurheartj/ehm226. PMID 17569678.

[6] Catella F, Healy D, Lawson JA, FitzGerald GA (1986). „11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation”. PNAS 83 (16): 5861–5865. DOI:10.1073/pnas.83.16.5861. PMC 386396. PMID 3461463.

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