(RS)-1-benzil-1,2,3,4-tetrahidroizohinolin N-metiltransferaza
(RS)-1-benzil-1,2,3,4-tetrahidroizohinolin N-metiltransferaza (EC 2.1.1.115, norretikulinska N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:(RS)-1-benzil-1,2,3,4-tetrahidroizohinolin N-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (RS)-1-benzil-1,2,3,4-tetrahidroizohinolin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.115 | ||||||||
| CAS broj | 132084-82-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- S-adenozil-L-metionin + (RS)-1-benzil-1,2,3,4-tetrahidroizohinolin S-adenozil-L-homocistein + N-metil-(RS)-1-benzil-1,2,3,4-tetrahidroizohinolin
Ovaj enzim ima široku supstratnu specifičnost za (RS)-1-benzil-1,2,3,4-tetrahidroizohinoline; uključujući koklaurin, norkoklaurin, izokoklaurin, norarmepavin, noretikulin i tetrahidropapaverin.
Reference uredi
- ↑ Frenzel, T., Zenk, M.H. (1990). „Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures”. Phytochemistry 29: 3491-3497.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.