(R)-2-halokiselinska dehalogenaza
(R)-2-halokiselinska dehalogenaza (EC 3.8.1.9, 2-haloalkanoidno kiselinska dehalogenaza (nespecifična), 2-haloalkanoidno kiselinska halidohidrolaza (nespecifična), D-2-halokiselinska dehalogenaza, D-DEX) je enzim sa sistematskim imenom (R)-2-halokiselina halidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (R)-2-halokiselinska dehalogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.8.1.9 | ||||||||
| CAS broj | 119345-29-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-2-halokiselina +H2O (S)-2-hidroksikiselina + halid
Ovaj enzim deluje na kiseline sa kratkim lancom, C2 do C4.
Reference uredi
- ↑ Smith, J.M., Harrison, K. and Colby, J. (1990). „Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23”. J. Gen. Microbiol. 136: 881-886. PMID 2380688.
- ↑ Leigh, J.A., Skinner, A.J. and Cooper, R.A. (1988). „Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species”. FEMS Microbiol. Lett. 49: 353-356.
- ↑ Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. (1996). „Bacterial 2-haloacid dehalogenases: Structures and catalytic properties”. Pure Appl. Chem. 68: 2097-2103.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.