(Fosfataza 2A protein)-leucin-karboksi metiltransferaza
(Fosfataza 2A protein)-leucin-karboksi metiltransferaza (EC 2.1.1.233, leucin karboksilna metiltransferaza-1, LCMT1) je enzim sa sistematskim imenom S-adenozil-L-metionin:(fosfataza 2A protein)-leucin O-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (Fosfataza 2A protein)-leucin-karboksi metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.233 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + [fosfataza 2A protein]-leucin S-adenozil-L-homocistein + [fosfataza 2A protein]-leucin metil estar
Ovaj enzim metiluje C-terminal leucin fosfataze 2A. On je ključni regulator proteinske fosfataze 2A. Metil estar hidrolizuje enzim EC 3.1.1.89 (proteinska fosfataza metilsteraza-1).
Reference uredi
- ↑ De Baere, I., Derua, R., Janssens, V., Van Hoof, C., Waelkens, E., Merlevede, W. and Goris, J. (1999). „Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue”. Biochemistry 38: 16539-16547. PMID 10600115.
- ↑ Tsai, M.L., Cronin, N. and Djordjevic, S. (2011). „The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A”. Acta Crystallogr. D Biol. Crystallogr. 67: 14-24. PMID 21206058.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.