(2-aminoetil)fosfonat—piruvat transaminaza
(2-aminoetil)fosfonat—piruvat transaminaza (EC 2.6.1.37, (2-aminoetil)fosfonatna transaminaza, (2-aminoetil)fosfonatna aminotransferaza, (2-aminoetil)fosfonsko kiselinska aminotransferaza, 2-aminoetilfosfonat-piruvatna aminotransferaza, 2-aminoetilfosfonatna aminotransferaza, 2-aminoetilfosfonatna transaminaza, AEP transaminaza, AEPT) je enzim sa sistematskim imenom (2-aminoetil)fosfonat:piruvat aminotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
(2-aminoetil)fosfonat—piruvat transaminaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.6.1.37 | ||||||||
CAS broj | 37277-91-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim je piridoksal-fosfatni protein. 2-Aminoetilarsonat može da zameni 2-aminoetilfosfonat kao supstrat.
Reference uredi
- ↑ La Nauze, J.M. and Rosenberg, H. (1968). „The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus”. Biochim. Biophys. Acta 165: 438-447. PMID 4982500.
- ↑ Dumora, C., Lacoste, A.-M. and Cassaigne, A. (1983). „Purification and properties of 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa”. Eur. J. Biochem. 133: 119-125. PMID 6406228.
- ↑ Lacoste, A.-M., Dumora, C., Balas, L., Hammerschmidt, F. and Vercauteren, J. (1993). „Stereochemistry of the reaction catalysed by 2-aminoethylphosphonate aminotransferase. A 1H-NMR study”. Eur. J. Biochem. 215: 841-844. PMID 8394813.
- ↑ Lacoste, A.-M., Dumora, C., Ali, B.R.S., Neuzil, E. and Dixon, H.B.F. (1992). „Utilization of 2-aminoethylarsonic acid in Pseudomonas aeruginosa”. J. Gen. Microbiol. 138: 1283-1287. PMID 1527499.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.