(R)-2-metilmalatna dehidrataza
(Preusmjereno sa stranice (-)-citramalate hydro-lyase)
(R)-2-metilmalatna dehidrataza (EC 4.2.1.35, citrakonatna hidrataza, citrakonaza, citramalatna hidrolijaza, (-)-citramalatna hidrolijaza, (R)-2-metilmalatna hidrolijaza) je enzim sa sistematskim imenom (R)-2-metilmalat hidrolijaza (formira 2-metilmaleat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (R)-2-metilmalatna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.35 | ||||||||
| CAS broj | 9027-92-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-2-metilmalat 2-metilmaleat + H2O
Za dejstvo ovog enzima je neophodan jon Fe2+.
Reference uredi
- ↑ Subramanian, S.S. and Raghavendra Rao, M.R. (1968). „Purification and properties of citraconase”. J. Biol. Chem. 243: 2367-2372. PMID 4296839.
- ↑ Raghavendra Rao, M.R., Subramanian, S.S., Rahatekar, H.I. and Paranjape, S.V. (1963). „Enzymatic hydration of citraconate to (-)citramalate”. Biochem. Biophys. Res. Commun. 12: 78-82. PMID 13973053.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.