(+)-Epikubenolna sintaza

(Preusmjereno sa stranice (+)-epicubenol synthase)

(+)-Epikubenolna sintaza (EC 4.2.3.64, farnezil pirofosfatna ciklaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-epikubenol).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(+)-Epikubenolna sintaza
Identifikatori
EC broj 4.2.3.64
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(2E,6E)-farnezil difosfat +H2O (+)-epikubenol + difosfat

Za dejstvo ovog enzima je neophodan jon Mg2+.

Reference uredi

  1. Cane, D.E., Tandon, M., and Prabhakaran, P.C. (1993). „Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate”. J. Am. Chem. Soc. 115: 8103-8106. 
  2. Cane, D.E. and Tandon, M. (1994). „Biosynthesis of (+)-epicubenol.”. Tetrahedron Lett. 35: 5355-5358. 
  3. Cane, D.E. and Tandon, M. (1995). „Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate”. J. Am. Chem. Soc. 117: 5602-5603. 
  4. Nabeta, K., Kigure, K., Fujita, M., Nagoya, T., Ishikawa, T., Okuyama, H. and Takasawa, T. (1995). „Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates”. J. Chem. Soc., Perkin Trans. 1: 1935-1939. 
  5. Nabeta, K., Fujita, M., Komuro, K., Katayama, K., and Takasawa, T. (1997). „In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus”. J. Chem. Soc., Perkin Trans. 1: 2065-2070. 

Literatura uredi

Spoljašnje veze uredi