Neoabietadienska sintaza (EC 4.2.3.132, AgAS, PtTPS-LAS) je enzim sa sistematskim imenom (+)-copali-difosfat difosfat-lijaza (ciklizacija, formira neoabietadien).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neoabietadienska sintaza
Identifikatori
EC broj 4.2.3.132
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(+)-kopalil difosfat neoabietadien + difosfat

Ovaj enzim je izolovan iz Abies grandis.

Reference uredi

  1. Peters, R.J., Flory, J.E., Jetter, R., Ravn, M.M., Lee, H.J., Coates, R.M. and Croteau, R.B. (2000). „A'bietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme”. Biochemistry 39: 15592-15602. PMID 11112547. 
  2. Zhou, K., Gao, Y., Hoy, J.A., Mann, F.M., Honzatko, R.B. and Peters, R.J. (2012). „Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis”. J. Biol. Chem. 287: 6840-6850. PMID 22219188. 
  3. Ro, D.K. and Bohlmann, J. (2006). „Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)”. Phytochemistry 67: 1572-1578. PMID 16497345. 

Literatura uredi

Spoljašnje veze uredi