Bornil difosfatna sintaza
(Preusmjereno sa stranice (+)-bornyl diphosphate synthase)
Bornil difosfatna sintaza (EC 5.5.1.8, bornil pirofosfatna sintaza, bornil pirofosfatna sintetaza, (+)-bornilpirofosfatna ciklaza, geranil-difosfatna ciklaza) je enzim sa sistematskim imenom (+)-bornil-difosfat lijaza (deciklizacija).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Bornil difosfatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.5.1.8 | ||||||||
| CAS broj | 72668-91-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- geranil difosfat (+)-bornil difosfat
Za dejstvo ovog enzima je neophodan jon Mn2+.
Reference uredi
- ↑ Croteau, R. and Karp, F. (1979). „Biosynthesis of monoterpenes: preliminary characterization of bornyl pyrophosphate synthetase from sage (Salvia officinalis) and demonstration that geranyl pyrophosphate is the preferred substrate for cyclization”. Arch. Biochem. Biophys. 198: 512-522. PMID 42356.
- ↑ Croteau, R., Gershenzon, J., Wheeler, C.J. and Satterwhite, D.M. (1990). „Biosynthesis of monoterpenes: stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to camphane and isocamphane monoterpenes”. Arch. Biochem. Biophys. 277: 374-381. PMID 2178556.
- ↑ Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1986). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 261: 13438-13445. PMID 3759972.
- ↑ Croteau, R., Felton, N.M. and Wheeler, C.J. (1985). „Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 260: 5956-5962. PMID 3997807.
- ↑ Croteau, R.B., Shaskus, J.J., Renstrom, B., Felton, N.M., Cane, D.E., Saito, A. and Chang, C. (1985). „Mechanism of the pyrophosphate migration in the enzymatic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates”. Biochemistry 24: 7077-7085. PMID 4084562.
- ↑ McGeady, P. and Croteau, R. (1995). „Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor”. Arch. Biochem. Biophys. 317: 149-155. PMID 7872777.
- ↑ Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998). „Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase”. J. Biol. Chem. 273: 14891-14899. PMID 9614092.
- ↑ Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W. (2002). „Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase”. Proc. Natl. Acad. Sci. USA 99: 15375-15380. PMID 12432096.
- ↑ Peters, R.J. and Croteau, R.B. (2003). „Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”. Arch. Biochem. Biophys. 417: 203-211. PMID 12941302.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.