(+)-Alfa-pinenska sintaza

(Preusmjereno sa stranice (+)-alfa-pinen sintaza)

(+)-Alfa-pinenska sintaza (EC 4.2.3.121, (+)-alfa-pinenska ciklaza, ciklaza I) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (+)-alfa-pinen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(+)-Alfa-pinenska sintaza
Identifikatori
EC broj 4.2.3.121
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
geranil difosfat (+)-alfa-pinen + difosfat

Ciklaza I iz Salvia officinalis formira jednake količine (-)-alfa-pinena i (-)-kamfena.

Reference uredi

  1. Gambliel, H. and Croteau, R. (1984). „Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration”. J. Biol. Chem. 259: 740-748. PMID 6693393. 
  2. Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1988). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene”. J. Biol. Chem. 263: 10063-10071. PMID 3392006. 
  3. Wagschal, K.C., Pyun, H.J., Coates, R.M. and Croteau, R. (1994). „Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 477-487. PMID 8109978. 
  4. Pyun, H.J., Wagschal, K.C., Jung, D.I., Coates, R.M. and Croteau, R. (1994). „Stereochemistry of the proton elimination in the formation of (+)- and (-)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 488-496. PMID 8109979. 
  5. Phillips, M.A., Savage, T.J. and Croteau, R. (1999). „Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers”. Arch. Biochem. Biophys. 372: 197-204. PMID 10562434. 
  6. Phillips, M.A., Wildung, M.R., Williams, D.C., Hyatt, D.C. and Croteau, R. (2003). „cDNA isolation, functional expression, and characterization of (+)-α-pinene synthase and (-)-α-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis”. Arch. Biochem. Biophys. 411: 267-276. PMID 12623076. 

Literatura uredi

Spoljašnje veze uredi