Zolmitriptan (Zomig, Zomigon, AscoTop, Zomigoro) je selektivan agonist serotoninskog receptora, 1B i 1D podtipova. On je triptan koji se koristi za tretman napada akutne migrene.[6][7]
Zolmitriptan
|
(IUPAC) ime
|
(S)-4-({3-[2-(dimetilamino)etil]-1H-indol-5-il}metil)-1,3-oksazolidin-2-on
|
Klinički podaci
|
Robne marke
|
Zomig
|
AHFS/Drugs.com
|
Monografija
|
Identifikatori
|
CAS broj
|
139264-17-8
|
ATC kod
|
N02CC03
|
PubChem[1][2]
|
60857
|
DrugBank
|
DB00315
|
ChemSpider[3]
|
54844
|
UNII
|
2FS66TH3YW Y
|
KEGG[4]
|
D00415 Y
|
ChEBI
|
CHEBI:10124 Y
|
ChEMBL[5]
|
CHEMBL1185 Y
|
Hemijski podaci
|
Formula
|
C16H21N3O2
|
Mol. masa
|
287,357 g/mol
|
SMILES
|
eMolekuli & PubHem
|
InChI |
InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1 Y Key: ULSDMUVEXKOYBU-ZDUSSCGKSA-N Y |
|
Farmakokinetički podaci
|
Bioraspoloživost
|
40% (oralno)
|
Vezivanje za proteine plazme
|
25%
|
Metabolizam
|
Hepatički (CYP1A2 posredovano, do aktivnog metabolita)
|
Poluvreme eliminacije
|
3 sata
|
Izlučivanje
|
Renalno (65%) i fekalno (35%)
|
Farmakoinformacioni podaci
|
Trudnoća
|
B3(AU) C(US)
|
Pravni status
|
℞-only (SAD)
|
Način primene
|
Oralno, nazalni sprej
|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- ↑ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.
Literatura
uredi
Spoljašnje veze
uredi