VUF-8430

VUF-8430
	Preferentno IUPAC ime 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
Identifikacija
Abrevijacija	VUF-8430
CAS registarski broj	98021-17-1
PubChem	3063228
ChemSpider	2323820
ChEMBL	CHEMBL1196470
Jmol-3D slike	Slika 1
SMILES
	NC(=N)NCCSC(N)=N
InChI
	InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9) ; Kod: GSYGTVNTZHFQQH-UHFFFAOYSA-N
Svojstva
Molekulska formula	C4H11N5S
Molarna masa	161.23 g mol−1
log P	-1,367
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

VUF-8430 je histaminski agonist^[5] koji je selektivan za H₄ tip receptora.^[6]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). „Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury”. Neuroimmunomodulation 14 (6): 317–25. DOI:10.1159/000125048. PMID 18401194.
↑ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). „Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.”. Journal of Medical Chemistry 49 (23): 6650–1. DOI:10.1021/jm060880d. PMID 17154494.

Spoljašnje veze uredi

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid18401194-5] Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). „Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury”. Neuroimmunomodulation 14 (6): 317–25. DOI:10.1159/000125048. PMID 18401194.

[6] Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). „Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.”. Journal of Medical Chemistry 49 (23): 6650–1. DOI:10.1021/jm060880d. PMID 17154494.

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