Uroporfirinogen-III sintaza
Uroporfirinogen-III sintaza (EC 4.2.1.75, porfobilinogenaza, uroporfirinogenska izomeraza, uroporfirinogen III kosintaza, URO-sintaza, hidroksimetilbilanska hidrolijaza (ciklizacija)) je enzim sa sistematskim imenom hidroksimetilbilan hidrolijaza (ciklizacija, formira uroporfirinogen-III).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Uroporfirinogen-III sintaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.2.1.75 | ||||||||
| CAS broj | 37340-55-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- hidroksimetilbilan uroporfirinogen III + H2O
U prisustvu enzima EC 2.5.1.61, hidroksimetilbilanske sintaze, ovaj enzim formira uroporfirinogen III iz porfobilinogena.
Reference uredi
- ↑ Battersby, A.R., Fookes, C.J.R., Matcham, G.W.J. and McDonald, E. (1980). „Biosynthesis of the pigments of life: formation of the macrocycle”. Nature 285: 17-21. PMID 6769048.
- ↑ Tsai, S.-F., Bishop, D.F. and Desnick, R.J. (1987). „Purification and properties of uroporphyrinogen III synthase from human erythrocytes”. J. Biol. Chem. 262: 1268-1273. PMID 3805019.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.