Urat oksidaza
Urat oksidaza (EC 1.7.3.3, urinsko kiselinska oksidaza, urikaza, urikaza II, uratna-oksidaza) je enzim sa sistematskim imenom urat:kiseonik oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Urat oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Tetramer urat oksidaze (Aspergillus flavus) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.7.3.3 | ||||||||
| CAS broj | 2594291 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- urat + O2 +H2O 5-hidroksiizourat +H2O2
Enzimu iz zrna soje, plesni Aspergillus flavus i Bacillus subtilis ne sadrže bakar, niti druge jone prelaznih metala.
Reference uredi
- ↑ London, M. and Hudson, P.B. (1956). „Purification and properties of solubilized uricase”. Biochim. Biophys. Acta 21: 290-298. PMID 13363909.
- ↑ Mahler, H.R., Hübscher, G. and Baum, H. (1955). „Studies on uricase. I. Preparation, purification, and properties of a cuproprotein”. J. Biol. Chem. 216: 625-641. PMID 13271340.
- ↑ Robbins, K.C., Barnett, E.L. and Grant, N.H. (1955). „Partial purification of porcine liver uricase”. J. Biol. Chem. 216: 27-35. PMID 13252004.
- ↑ Kahn, K. and Tipton, P.A. (1998). „Spectroscopic characterization of intermediates in the urate oxidase reaction”. Biochemistry 37: 11651-11659. PMID 9709003.
- ↑ Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prange, T., Castro, B. and Mornon, J.-P. (1997). „Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution”. Nat. Struct. Biol. 4: 947-952. PMID 9360612.
- ↑ Imhoff, R.D., Power, N.P., Borrok, M.J. and Tipton, P.A. (2003). „General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad”. Biochemistry 42: 4094-4100. PMID 12680763.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.