Triplatin tetranitrat (rINN; BBR3464) je citotoksični lek baziran na platini koji je prošao kroz Klinička ispitivanja za tretmn ljudskog kancera.[3] Leko formira adukte sa ćelijskom DNK, čime se sprečava DNK transkripcija i replikacija, te se indukuje apoptoza. Drugi lekovi protiv kancera koji sadrže platinu su cisplatin, karboplatin, i oksaliplatin.
Triplatin tetranitrat
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Klinički podaci
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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56841764
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Hemijski podaci
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Formula
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C12H54Cl2N14O12Pt3
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Mol. masa
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1242,8018 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/2C6H14N2.CH3.2ClH.4HNO3.5H2N.3Pt/c2*7-5-3-1-2-4-6-8;;;;4*2-1(3)4;;;;;;;;/h2*7-8H,1-6H2;1H3;2*1H;4*(H,2,3,4);5*1H2;;;/q2*-2;-1;;;;;;;5*-1;2*+1;+4/p-2 Key: JNZIJTVZGOHQBD-UHFFFAOYSA-L |
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Sinonimi
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BBR3464, BBR 3464, BBR-3464, C114062, ((trans-PtCl(NH3)2)2(trans-Pt(NH3)2(NH2(CH2)6NH2)2))(NO3)4
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.; Oun, Rabbab (2010). „The status of platinum anticancer drugs in the clinic and in clinical trials”. Dalton Transactions 39 (35): 8113–27. DOI:10.1039/C0DT00292E. PMID 20593091.