Tentoksilizin
Tentoksilizin (EC 3.4.24.68, tetanus neurotoksin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tentoksilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.68 | ||||||||
| CAS broj | 107231-12-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza -Gln76-Phe- veze u sinaptobrevinu
Ovaj cinkov enzim proizvodi Clostridium tetani.
Reference uredi
- ↑ Fujii, N., Kimura, K., Yashiki, T., Tsuzuki, K., Moriishi, K., Yokosawa, N., Syuto, B. and Oguma, K. (1992). „A zinc-protease specific domain in botulinum and tetanus neurotoxins”. Microbiol. Intern. 36: 213-220. PMID 1376283.
- ↑ Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Polverino de Laureto, P., DasGupta, B.R. and Montecucco, C. (1992). „Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin”. Nature 359: 832-834. PMID 1331807.
- ↑ Schiavo, G., Rossetto, O., Santucci, A., DasGupta, B.R. and Montecucco, C. (1992). „Botulinum neurotoxins are zinc proteins”. J. Biol. Chem. 267: 23479-23483. PMID 1429690.
- ↑ Montecucco, C. and Schiavo, G. (1994). „Mechanism of action of tetanus and botulinum neurotoxins”. Mol. Microbiol. 8: 1-13. PMID 7527117.
- ↑ Schiavo, G. and Montecucco, C. (1995). „Tetanus and botulism neurotoxins”. Methods Enzymol. 248: 643-652. PMID 7674951.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.