T-Plasminogeni aktivator

T-Plasminogeni aktivator (EC 3.4.21.68, tkivni plazminogenski activator, plazminogenski aktivator, tkivni-tip, tkivni tip plazminogenskog aktivatora, tPA, t-PA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

T-Plasminogeni aktivator
Identifikatori
EC broj 3.4.21.68
CAS broj 139639-23-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Specifično razlaganje Arg-Val veze u plazminogenu čime se formira plazmin

Ova peptidaza je prisutna u širokom opsegu tipova tkiva, a posebno u endotelnim ćelijama.

Reference uredi

  1. Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. (1983). „Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli”. Nature 301: 214-221. PMID 6337343. 
  2. Loskutoff, D.J. and Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293-302. PMID 3148826. 
  3. Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. (1988). „The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage”. Biochim. Biophys. Acta 952: 245-254. PMID 2962643. 
  4. Verheijen, J.H. (1988). „Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma”. Methods Enzymol. 163: 302-309. PMID 3148827. 
  5. Gerard, R.D. and Meidell, R.S. (1989). „Regulation of tissue plasminogen activator expression”. Annu. Rev. Physiol. 51: 245-262. PMID 2496643. 
  6. Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 

Literatura uredi

  • Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 

Spoljašnje veze uredi