Sumpor dioksigenaza
Sumpor dioksigenaza (EC 1.13.11.18, sumporna oksigenaza, sumpor:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom S-sulfanilglutation:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sumpor dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.18 | ||||||||
| CAS broj | 37256-58-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- sumpor + O2 +H2O sulfit + 2 H+ (sveukupna reakcija)
- (1a) glutation + sumpor S-sulfanilglutation (spontana reakcija)
- (1b) S-sulfanilglutation + O2 + H2O glutation + sulfit + 2 H+
Ovaj enzim sadrži gvožđe. Glutation (GSH) ima katalitičku ulogu u aktivaciji elemernog sumpora, ali se ne konzumira tokom reakcije.
Reference uredi
- ↑ Suzuki, I. and Silver, M. (1966). „The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli”. Biochim. Biophys. Acta 122: 22-33. PMID 5968172.
- ↑ Rohwerder, T. and Sand, W. (2003). „The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp”. Microbiology 149: 1699-1710. PMID 12855721.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.