Sulfit reduktaza (NADPH)
Sulfit reduktaza (NADPH) (EC 1.8.1.2, sulfit (redukovani nikotinamid adenin dinukleotid fosfat) reduktaza, NADPH-sulfitna reduktaza, NADPH-zavisna sulfitna reduktaza, H2S-NADP oksidoreduktaza, sulfitna reduktaza (NADPH2)) je enzim sa sistematskim imenom vodonik-sulfid:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sulfit reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.2 | ||||||||
| CAS broj | 9029-35-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- vodonik sulfid + 3 NADP+ + 3H2O sulfit + 3 NADPH + 3 H+
Ovaj enzim je gvozdeni flavoprotein (FAD i FMN).
Reference uredi
- ↑ Hilz, H., Kittler, M. and Knape, G. (1959). „Die Reduktion von Sulfate in der Hefe”. Biochem. Z. 332: 151-166. PMID 14401842.
- ↑ Siegel, L.M., Murphy, M.J. and Kamin, H. (1973). „Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups”. J. Biol. Chem. 248: 251-264. PMID 4144254.
- ↑ Yoshimoto, A. and Sato, R. (1968). „Studies on yeast sulfite reductase. I. Purification and characterization”. Biochim. Biophys. Acta 153: 555-575. PMID 4384979.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.