Stizolobinat sintaza
Stizolobinat sintaza (EC 1.13.11.30, stizolobinatna sintaza) je enzim sa sistematskim imenom 3,4-dihidroksi-L-fenilalanin:kiseonik 2,3-oksidoreduktaza (reciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Stizolobinat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.30 | ||||||||
| CAS broj | 65979-38-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-dopa + O2 5-(L-alanin-3-il)-2-hidroksi-cis,cis-mukonat 6-semialdehid
Intermedijer podleže zatvaranju prstena oksidaciji, sa NAD(P)+ kao akceptorom.
Reference uredi
- ↑ Saito, K. and Komamine, A. (1976). „Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo”. Eur. J. Biochem. 68: 237-243. PMID 9285.
- ↑ Saito, K. and Komamine, A. (1978). „Biosynthesis of stizolobinic acid and stizolobic acid in higher plants”. Eur. J. Biochem. 82: 385-392. PMID 624278.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.