Sarkozin dehidrogenaza
Sarkozin dehidrogenaza (EC 1.5.8.3, sarkozinska N-demetilaza, monometilglicinska dehidrogenaza, sarkozin:(akceptor) oksidoreduktaza (demetilacija)) je enzim sa sistematskim imenom sarkozin:elektron-transfer flavoprotein oksidoreduktaza (demetilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sarkozin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.8.3 | ||||||||
| CAS broj | 93389-49-2&title= 37228-65-2, 93389-49-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- sarkozin + H2O + elektron-transfer flavoprotein glicin + formaldehid + redukovani elektron-transfer flavoprotein
Ovaj enzim je flavoprotein (FMN). Tetrahidrofolat je takođe supstrat, pri čemu se konvertuje u N5,N10-metilintetrahidrofolat.
Reference uredi
- ↑ Hoskins, D.D. and MacKenzie, C.G. (1961). „Solubilization and electron transfer flavoprotein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase”. J. Biol. Chem. 236: 177-183. PMID 13716069.
- ↑ Frisell, W.R. and MacKenzie, C.G. (1962). „Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase”. J. Biol. Chem. 237: 94-98. PMID 13895406.
- ↑ Steenkamp, D.J. and Husain, M. (1982). „The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases”. Biochem. J. 203: 707-715. PMID 6180732.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.