Salutaridin sintaza
Salutaridin sintaza (EC 1.14.21.4, (R)-retikulinska oksidaza (C-C fenolno spajanje)) je enzim sa sistematskim imenom (R)-retikulin,NADPH:kiseonik oksidoreduktaza (C-C fenolno spajanje).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Salutaridin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.21.4 | ||||||||
| CAS broj | 149433-84-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-retikulin + NADPH + H+ + O2 salutaridin + NADP+ + 2H2O
Ovaj enzim je hem-tiolatni protein (P-450). On formira morfinanski alkaloid salutaridin putem intramolekularne fenolne oksidacije retikulina bez inkorporacije kiseonika u produkt.
Reference uredi
- ↑ Gerady, R. and Zenk, M.H. (1993). „Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum”. Phytochemistry 32: 79-86.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.