SHA-68 je lek koji deluje kao selektivni, ne-peptidni antagonist neuropeptidnog S receptora NPSR. U životinjskim studijama on izaziva uznemirenost, i blokira stimulišuće dejstvo neuropeptida S.[3][4]
SHA-68
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(IUPAC) ime
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N-[(4-fluorofenil)metil]-3-okso-1,1-difenil-5,6,8,8a-tetrahidro-[1,3]oksazolo[3,4-a]pirazin-7-karboksamid
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Klinički podaci
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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11374217
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Hemijski podaci
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Formula
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C26H24FN3O3
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Mol. masa
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445.484 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C26H24FN3O3/c27-22-13-11-19(12-14-22)17-28-24(31)29-15-16-30-23(18-29)26(33-25(30)32,20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23H,15-18H2,(H,28,31) Y Key: SFRQIPRTNYHJHP-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Fukatsu K, Nakayama Y, Tarui N, Mori M, Matsumoto H, Kurasawa O, Banno H. Bicyclic Piperazine Compound and Use Thereof. PCT Patent WO 2005/021555 A1. Published 26.08.2004
- ↑ Okamura N, Habay SA, Zeng J, Chamberlin AR, Reinscheid RK (June 2008). „Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-apyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor”]. The Journal of Pharmacology and Experimental Therapeutics 325 (3): 893–901. DOI:10.1124/jpet.107.135103. PMC 2583099. PMID 18337476.
Spoljašnje veze
uredi