S-metil-5'-tioadenozin fosforilaza
S-metil-5'-tioadenozin fosforilaza (EC 2.4.2.28, 5'-metiltioadenozin nukleozidaza, 5'-dezoksi-5'-metiltioadenozin fosforilaza, MTA fosforilaza, MeSAdo fosforilaza, MeSAdo/Ado fosforilaza, metiltioadenozin fosforilaza, metiltioadenozin nukleozid fosforilaza, 5'-metiltioadenozin:fosfat metiltio-D-ribozil-transferaza, S-metil-5-tioadenozin fosforilaza, S-metil-5-tioadenozin:fosfat S-metil-5-tio-alfa-D-ribozil-transferaza) je enzim sa sistematskim imenom S-metil-5'-tioadenozin:fosfat S-metil-5-tio-alfa-D-ribozil-transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
S-metil-5'-tioadenozin fosforilaza | |||||||||
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S-metil-5'-tioadenozin fosforilaza trimer, Human | |||||||||
Identifikatori | |||||||||
EC broj | 2.4.2.28 | ||||||||
CAS broj | 61970-06-7 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- S-metil-5'-tioadenozin + fosfat adenin + S-metil-5-tio-alfa-D-riboza 1-fosfat
Ovaj enzim takođe deluje na 5'-dezoksiadenozin i druge analoge sa 5'-dezoksi grupama.
Reference uredi
- ↑ Carteni-Farina, M., Oliva, A., Romeo, G., Napolitano, G., De Rosa, M., Gambacorta, A. and Zappia, V. (1979). „5′-Methylthioadenosine phosphorylase from Caldariella acidophila. Purification and properties”. Eur. J. Biochem. 101: 317-324. PMID 118001.
- ↑ Garbers, D.L. (1978). „Demonstration of 5′-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung”. Biochim. Biophys. Acta 523: 82-93. PMID 415762.
- ↑ Pegg, A.E. and Williams-Ashman, H.G. (1969). „Phosphate-stimulated breakdown of 5′-methylthioadenosine by rat ventral prostate”. Biochem. J. 115: 241-247. PMID 5378381.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.