Protokatehuat 3,4-dioksigenaza
Protokatehuat 3,4-dioksigenaza (EC 1.13.11.3, protokatehuatna oksigenaza, protokatehuinska kiselina oksidaza, protokatehuinska 3,4-dioksigenaza, protokatehuinska 3,4-oksigenaza) je enzim sa sistematskim imenom protokatehuat:kiseonik 3,4-oksidoreduktaza (deciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Protokatehuat 3,4-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Hetero24mer protokatehuat 3,4-dioksigenaze (Pseudomonas putida) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.13.11.3 | ||||||||
| CAS broj | 9029-47-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3,4-dihidroksibenzoat + O2 3-karboksi-cis,cis-mukonat
Za rad ovog enzima neohodan je Fe3+. Enzim koji učestvuje u degradaciji aromatičnih jedinjenja, katalizuje intradiolnu adiciju atoma molekulskog kiseonika.
Reference uredi
- ↑ Fujisawa, H. and Hayaishi, O. (1968). „Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization”. J. Biol. Chem. 243: 2673-2681. PMID 4967959.
- ↑ Gross, S.R., Gafford, R.D. and Tatum, E.L. (1956). „The metabolism of protocatechuic acid by Neurospora”. J. Biol. Chem. 219: 781-796. PMID 13319299.
- ↑ Stanier, R.Y. and Ingraham, J.L. (1954). „Protocatechuic acid oxidase”. J. Biol. Chem. 210: 799-820. PMID 13211618.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.