N-n-Propilnorapomorfin (NPA) je derivat aporfina koji deluje kao dopaminski agonist. On je blisko srodan sa apomorfinom.[4][5] Pokazano je da kod glodara između ostalog proizvodi hiperaktivnost, stereotipiju, hipotermiju, antinocepciju, i erekciju.[6][7][8][9]
Propilnorapomorfin
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(IUPAC) ime
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(6aS)-6-propil-5,6,6a,7-tetrahidro-4H-dibenzo[de,g]hinolin-10,11-diol
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Klinički podaci
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Identifikatori
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CAS broj
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57559-68-9
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ATC kod
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nije dodeljen
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PubChem[1][2]
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5311191
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ChemSpider[3]
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4470712
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Hemijski podaci
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Formula
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C19H21NO2
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Mol. masa
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295,38 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3 Y Key: BTGAJCKRXPNBFI-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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Uncontrolled
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Način primene
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Oralno
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Miller RJ, Kelly PH, Neumeyer JL (January 1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain”. European Journal of Pharmacology 35 (1): 77–83. DOI:10.1016/0014-2999(76)90302-2. PMID 943290.
- ↑ Creese I, Padgett L, Fazzini E, Lopez F (July 1979). „3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors”. European Journal of Pharmacology 56 (4): 411–2. DOI:10.1016/0014-2999(79)90274-7. PMID 477735.
- ↑ Menon MK, Clark WG, Neumeyer JL (November 1978). „Comparison of the dopaminergic effects of apomorphine and (-)-N-n-propylnorapomorphine”. European Journal of Pharmacology 52 (1): 1–9. DOI:10.1016/0014-2999(78)90015-8. PMID 569056.
- ↑ Riffee WH, Wilcox RE, Smith RV (March 1979). „Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice”. European Journal of Pharmacology 54 (3): 273–7. DOI:10.1016/0014-2999(79)90086-4. PMID 570924.
- ↑ Neumeyer JL, Reinhard JF, Dafeldecker WP, et al. (January 1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine”. Journal of Medicinal Chemistry 19 (1): 25–9. DOI:10.1021/jm00223a006. PMID 942751.
- ↑ Benassi-Benelli A, Ferrari F, Quarantotti BP (December 1979). „Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats”. Archives Internationales De Pharmacodynamie Et De Thérapie 242 (2): 241–7. PMID 44457.
Spoljašnje veze
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