Prokolagen glukoziltransferaza
Prokolagen glukoziltransferaza (EC 2.4.1.66, galaktozilhidroksilizinska glukoziltransferaza, kolagenska glukoziltransferaza, kolagen hidroksilizilna glukoziltransferaza, galaktozilhidroksilizilna glukoziltransferaza, UDP-glukoza-kolagenglukoziltransferaza, uridin difosfoglukoza-kolagenska glukoziltransferaza, UDP-glukoza:5-(D-galaktoziloksi)-L-lizin-prokolagenska D-glukoziltransferaza) je enzim sa sistematskim imenom UDP-glukoza:(2S,5R)-5-O-(beta-D-galaktozil)-5-hidroksi-L-lizin-(prokolagen) D-glukoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Prokolagen glukoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.66 | ||||||||
| CAS broj | 2603666 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-glukoza + (2S,5R)-5-O-(beta-D-galaktozil)-5-hidroksi-L-lizin-[prokolagen] UDP + (2S,5R)-5-O-[alfa-D-glukozil-(1->2)-beta-D-galaktozil]-5-hidroksi-L-lizin-[prokolagen]
Ovaj enzim učestvuje u sintezi ugljeno hidratnih jedinica u komplementu, cf. EC 2.4.1.50 (prokolagenska galaktoziltransferaza).
Reference uredi
- ↑ Bosmann, H.B. and Eylar, E.H. (1968). „Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase”. Biochem. Biophys. Res. Commun. 30: 89-94. PMID 5637038.
- ↑ Bosmann, H.B. and Eylar, E.H. (1968). „Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses”. Nature 218: 582-583. PMID 4968368.
- ↑ Butler, W.T. and Cunningham, L.W. (1966). „Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen”. J. Biol. Chem. 241: 3882-3888. PMID 4288358.
- ↑ Kivirikko, K.I. and Myllyla, R. (1979). Hall, D.A. and Jackson, D.S.. ur. International Review of Connective Tissue Research. 8. New York: Academic Press. str. 23-.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Kivirikko, K.I. and Myllyla, R. (1979). Hall, D.A. and Jackson, D.S.. ur. International Review of Connective Tissue Research. 8. New York: Academic Press. str. 23-.