Porfobilinogenska sintaza
Porfobilinogenska sintaza (EC 4.2.1.24, aminolevulinatna dehidrataza, delta-aminolevulinatna dehidrataza, delta-aminolevulinsko kiselinska dehidraza, delta-aminolevulinsko kiselinska dehidrataza, aminolevulinska dehidrataza, delta-aminolevulinska dehidrataza, 5-levulinsko kiselinska dehidrataza, 5-aminolevulinatna hidrolijaza (dodaje 5-aminolevulinat i vrši ciklizaciju)) je enzim sa sistematskim imenom 5-aminolevulinatna hidrolijaza (dodaje 5-aminolevulinat i ciklizuje; formira porfobilinogen).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Porfobilinogenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| DALA dehidrataza | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.24 | ||||||||
| CAS broj | 9036-37-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2 5-aminolevulinat porfobilinogen + 2H2O
Ovaj fungalni enzim je metaloprotein.
Reference uredi
- ↑ Gibson, K.D., Neuberger, A. and Scott, J.J. (1955). „The purification and properties of δ-aminolaevulic acid dehydrase”. Biochem. J. 61: 618-629. PMID 13276347.
- ↑ Komai, H. and Neilands, J.B. (1969). „The metalloprotein nature of Ustilago δ-aminolevulinate dehydratase”. Biochim. Biophys. Acta 171: 311-320. PMID 5773436.
- ↑ Yamasaki, H. and Moriyama, T. (1971). „δ-Aminolevulinic acid dehydratase of Mycobacterium phlei”. Biochim. Biophys. Acta 227: 698-705. PMID 4998716.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.