Pikornain 3C
Pikornain 3C (EC 3.4.22.28, pikornavirusna endopeptidaza 3C, poliovirusna proteaza 3C, rinovirusna proteaza 3C, proteaza 3C bolesti slinavka i šap, poliovirusna proteinaza 3C, rinovirusna proteinaza 3C, koksakievirusna 3C proteinaza, proteinaza 3C virusa bolesti slinavka i šap, 3C proteaza, 3C proteinaza, cisteinska proteinaza 3C, hepatitis A virusna 3C proteinaza, proteaza 3C, proteinaza 3C srodana sa nepovirusom prstenastih mrlja paradajza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pikornain 3C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.28 | ||||||||
| CAS broj | 97162-88-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selektivno razlaganje Gln-Gly veze u poliovirusnom poliproteinu. U drugim pikornavirusnim reakcijama Glu može da bude supstituisan sa Gln, i Ser ili Thr za Gly
Ovaj enzim izražavaju entero-, rino-, afto- i kardiovirusi.
Reference uredi
- ↑ Ivanoff, L.A., Towatari, T., Ray, J., Korant, B.D. and Petteway, S.R. (1986). „Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli”. Proc. Natl Acad. Sci. USA 83: 5392-5396. PMID 3016701.
- ↑ Bazan, J.F. and Fletterick, R.J. (1988). „Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications”. Proc. Natl Acad. Sci. USA 85: 7872-7876. PMID 3186696.
- ↑ Kräusslich, H.-G. and Wimmer, E. (1988). „Viral proteinases”. Annu. Rev. Biochem. 57: 701-754. PMID 3052288.
- ↑ Nicklin, M.J.H., Harris, K.S., Pallai, P.V. and Wimmer, E. (1988). „Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro”. J. Virol. 62: 4586-4593. PMID 2846872.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.