Peptid-N4-(N-acetil-beta-glukozaminil)asparaginska amidaza
Peptid-N4-(N-acetil-beta-glukozaminil)asparaginska amidaza (EC 3.5.1.52, glikopeptidna N-glikozidaza, glikopeptidaza, N-oligosaharidna glikopeptidaza, N-glikanaza, Džek-bin glikopeptidaza, PNGaza A, PNGaza F) je enzim sa sistematskim imenom N-vezani-glikopeptid-(N-acetil-beta-D-glukozaminil)-L-asparagin amidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peptid-N4-(N-acetil-beta-glukozaminil)asparaginska amidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.52 | ||||||||
| CAS broj | 83534-39-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- hidroliza N4-(acetil-beta-D-glukozaminil)asparaginskog ostatka u kome glukozaminski ostatak može dalje da bude glikozilisan, čime se formira (supstituisani) N-acetil-beta-D-glukozaminilamin i peptid koji sadrži aspartatni ostatak
Ovaj enzim ne deluje na (GlcNAc)Asn.
Reference uredi
- ↑ Plummer, T.H., Jr. and Tarentino, A.L. (1981). „Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide: N-glycosidase”. J. Biol. Chem. 256: 10243-10246. PMID 7287707.
- ↑ Takahashi, N. (1977). „Demonstration of a new amidase acting on glycopeptides”. Biochem. Biophys. Res. Commun. 76: 1194-1201. PMID 901470.
- ↑ Takahashi, N. and Nishibe, H. (1978). „Some characteristics of a new glycopeptidase acting on aspartylglycosylamine linkages”. J. Biochem. (Tokyo) 84: 1467-1473. PMID 738997.
- ↑ Tarentino, A.L., Gomez, C.M. and Plummer, T.H., Jr. (1985). „Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F”. Biochemistry 24: 4665-4671. PMID 4063349.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.